| abstract |
Disclosed are lipid nanoparticles, pharmaceutical compositions comprising the lipid nanoparticles, and methods of using thereof (e.g., for the treatment of cancer). In some examples, the lipid nanoparticles can comprise a therapeutic cargo encapsulated in the lipid nanoparticles that comprises a functional nucleic acid which modulates the expression of Akt-1 (e.g., an antisense oligonucleotide targeted to a portion of a nucleic acid encoding Akt-1) and a functional nucleic acid which modulates the expression of Bcl-2 (e.g., an antisense oligonucleotide targeted to a portion of a nucleic acid encoding Bcl-2). |