| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y30-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-1269
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/H01F1-344
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1857
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/H01F1-0054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5153
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-0515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4839 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y30-00 |
| filingDate |
2019-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bde8dd5a38fe830e02e133d1be80e97a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f1cce26b15787bc660fc415ae16906e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa7669a792a4a0e02fbb5de9108eb45f |
| publicationDate |
2020-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020041564-A1 |
| titleOfInvention |
Depth-independent method for in-vivo drug release monitoring and quantification based on magnetic particle imaging |
| abstract |
A non-invasive drug release monitoring and quantification method and system is provided using magnetic particle imaging to monitor in vivo drug release. A living body is imaged with a magnetic particle imager after the living body has been injected with a nanocomposite composed of a biodegradable polymer shell layer containing a cluster of magnetic nanoparticles and a drug. A magnetic particle signal is detected and obtained which represents the release of magnetic nanoparticles from the PLGA shell layer, which is the result of a disassembly of the biodegradable polymer shell layer due to biological degradation of the biodegradable polymer shell layer in an acidic environment of the living body resulting in drug release and magnetic nanoparticle release. The release of the drug in the living body is quantified using a previously obtained reference linear relationship defined between the magnetic particle signal and the drug release rate. |
| priorityDate |
2018-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |