| abstract |
Provided are miR-221/222 and inhibitors thereof for use in preparing drugs and detection targets for regulating liver fat deposition, liver fibrosis, and hepatocellular carcinoma. The effect is achieved by inhibiting the activity of miR-221 and/or miR-222 to reduce the liver fat infiltration level, the deposition of liver collagen fibers, plasma cholesterol level, serum transaminase and improve insulin resistance, thereby inhibiting malignant proliferation of liver cells. |