http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020037160-A2

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publicationDate 2020-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020037160-A2
titleOfInvention Rapid diagnostics of mycobacteria with lectin conjugated particles
abstract The present disclosure is generally directed to methods and systems for the rapid detection of mycobacteria in samples using lectin-conjugated silica coated magnetic nanoparticles (SMNPs). In this work, carbohydrates on the cell wall of the mycobacteria serve as binding sites for lectins conjugated on the surface of lectin-conjugated SMNPs. As the target species of mycobacteria bind to lectin-conjugated SMNPs, a precipitate forms, which can be magnetically separated from the bulk test solution to visually indicate the presence of the target species of mycobacteria. The present disclosure is utilized as an inexpensive and rapid point of care system in one embodiment. In another embodiment, the methods and systems are integrated into a lateral flow assay for rapid detection of the target species of mycobacteria. In yet another embodiment, the methods and systems are utilized to create a microfluidic detection device with increased sensitivity to mycobacteria in a sample.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022117430-A1
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type http://data.epo.org/linked-data/def/patent/Publication

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