http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020035162-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a047d443295f67c774db745bb487751d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F23-413 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F2101-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F23-4145 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F23-4105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-168 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F29-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01F23-43 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2019-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a87ea49a84680c4d1fdee5e26e6bb06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16f4664c3382030c8d61b1f656a4d083 |
| publicationDate | 2020-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020035162-A1 |
| titleOfInvention | Method for encapsulating active substances agents in liposomes |
| abstract | The invention relates to a method for encapsculating active ingredients agents in liposomes, which include an active agent solution encapsulated by with a bilayer formed by two monomolecular layers formed by amphiphilic compounds, wherein the method comprises the following steps: (a) providing the active agent solution; (b) providing an emulsion by emulsifying the active agent solution in a first fluid liquid that cannot be mixed with the solvent thereof in the presence of the amphiphilic compound, obtaining pre-liposomes; (c) providing a liquid phase that cannot be mixed with the first liquid of the emulsion; (d) bringing the emulsion in contact with the liquid phase, forming a phase boundary, in order to enrich the amphiphilic compound here; and (e) centrifuging the contacting emulsion and the liquid phase, which are in contact with one another via the phase boundary, in order to transfer the pre-liposomes out of the emulsion into the liquid phase, wherein, whereinwhen passing the phase boundary, the amphiphilic compound enriched there accumulates on the monomolecular inner layer of the pre-liposomes, forming a monomolecular outer layer, in order to generate the bilayer. In order to prevent the formation of organogels as a result of an excessive accumulation of the amphiphilic compound at the phase boundary, according to the invention, the first liquid of the emulsion is selected in such a way that the solubility of the amphiphilic compound in the first liquid is max. 1 x 10-4 mol/l. |
| priorityDate | 2018-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.