http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020034286-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eac2f8eff077c4682236f6b66083d39a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 2018-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb790cdb397d132568a1488efd33aae7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00597932a926cbc1b73e2a92db7fb91a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41175abb28d698e2434b267e76b5d3c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d8bd62a5084b5ddd537508770b0fcf0 |
| publicationDate | 2020-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020034286-A1 |
| titleOfInvention | Method for preparing plecanatide |
| abstract | A preparation method of Plecanatide comprises the following steps: 1) sequentially coupling an amino acid at position 16-7 on a solid-phase synthetic resin according to a Fmoc solid-phase synthesis strategy; 2) after removal of the Fmoc protecting group, processing a reagent for removing a Mmt protecting group and removing the side-chain Mmt protecting group of Cys at positions 7 and 15; 3) forming through bonding reaction a disulfide bond between Cys at position 7 and Cys at position 15; 4) according to the Fmoc solid-phase synthesis strategy, sequentially coupling an amino acid at position 6-1; 5) removing the Fmoc protecting group, and completing a disulfide bond between Cys at position 4 and Cys at position 12 through oxidation reaction; and 6) removing all the side-chain protecting groups, pyrolyzing the resin by using a cracking reagent, and precipitating by adding diethyl ether to obtain Plecanatide. The method is simple and efficient. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114044813-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114044813-B |
| priorityDate | 2018-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.