http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020024500-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_750ffd3c409c5b00d8868a7d8168e884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-3322 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-332 |
| filingDate | 2018-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b5b13dae17e7af45c3e93e9abb31729 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca9ba608f826636836cc4323c8197ef3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_612850cb9749d3e4f457eaca2b4c136d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a49a78c898f8664e7052491b543f0a96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72a24fef0dca6be51a6ad188935bbeab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ab7095886349a5d4ba0cd85ba18eadd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e67de580fc3f256d4ec7ac2e165c6a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a161f03e23c8bb1b91ece2453426e68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d781155ccb5df6d4856356621cb333cf |
| publicationDate | 2020-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020024500-A1 |
| titleOfInvention | Synthesis method for low-transoleate content polysorbate 80 for injection |
| abstract | A synthesis method for low-transoleate content polysorbate 80 for injection, comprising the following synthesis steps: mixing polyoxyethylene (20) sorbitol anhydride and high-purity low-carbon oleic acid alcohol ester according to a certain ratio, performing transesterification reaction under the action of a catalyst and in vacuum, and then performing refinement, sterilization, and removal of a pyrogen to obtain the polysorbate 80 for injection. The mass ratio of the polyoxyethylene (20) sorbitol anhydride to the high-purity low-carbon oleic acid alcohol ester ranges from 1:0.3 to 1:0.5. Compared with other methods, the method has the advantages as follows: the reaction temperature is lowered, conversion between cis-trans isomers of the oleic acid is effectively inhibited, so that the content of transoleate in the polysorbate 80 is reduced to be lower than or equal to 0.3%, and the chroma (APHA) is reduced to be lower than or equal to 30, and the biosafety of the polysorbate 80 is improved, moreover, the process operations are simplified, the process production efficiency is improved, and the production costs are reduced. |
| priorityDate | 2018-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.