| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28a89f8dab024e02ae765d1273e716f1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6806 |
| filingDate |
2019-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_265977062c3cc4674f7fbee8e04c1b26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c14260daaacb1857e9b6ea8658238ec6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bbdfdbac2f9168f0a16d6ec50dcf8f2 |
| publicationDate |
2020-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2020021099-A1 |
| titleOfInvention |
High resolution detection of dna abasic sites |
| abstract |
The present invention provides method of labelling a nucleic acid containing an abasic (AP) site. The method includes the step of reacting a nucleic acid comprising an AP site with an aldehyde probe, such that the probe covalently binds to the AP site to produce a nucleic acid labelled with the probe; optionally oxidising the nucleic acid labelled with the probe; optionally isolating the labelled nucleic acid, and selectively cleaving the nucleic acid at the AP site to produce nucleic acid fragments. |
| priorityDate |
2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |