http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020021052-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07d5dcbb9f91a44c19e14317e706f590 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_286b9e898c13088362dacd021c0bfc80 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5123 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2019-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_209c64c876238fa6de895ce6115aebeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07ac9d7388f8a67b98887649a2c643ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2f19bb9e902a5ebb9881af22ab2cfd8 |
| publicationDate | 2020-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020021052-A2 |
| titleOfInvention | Use of acyclic terpene alcohols for enhancing the antimicrobial activity of colistin |
| abstract | Colistin is an old polypeptide antibiotic widely used in food-producing animals, particularly in pig production as oral group treatment and metaphylaxis against Enterobacteriaceae digestive infections after weaning. In human, the use of colistin is nowadays recommended as a last resort for the treatment of multidrug-resistant bacteria. But, the discovery in 2015 of a transferable plasmid-encoded colistin resistance gene MCR-1 raised an important public health problem. Also, to keep this antibiotic as a last resort antibiotic a way to tackle this MCR-1 mechanism would be very useful. The inventors have studied the diminution of colistin MIC (minimal inhibitory concentration), against E.coli encoded with MCR-1 gene (MIC= 8 mg/L) and its control (MIC= 0.25 mg/L), in the presence of increasing concentrations of an acyclic terpene alcohol (e.g. farnesol or geraniol) They show that the acyclic terpene alcohol, in particular farnesol) is capable of restoring colistin activity against MCR-1 E.coli, allowing using low colistin concentrations, while, preventing bacterial regrowth. Thus the present invention relates to use of acyclic terpene alcohols for enhancing the antimicrobial activity of colistin. |
| priorityDate | 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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