| abstract |
The present disclosure provides compositions and methods for modulating expression of an antigen-specific binding protein by a host cell, such as a T cell. In certain aspects, trigger polypeptides are provided that can modulate expression of a binding protein, such as a CAR or a TCR specific for ROR1, when a cell-surface expressed trigger polypeptide binds to an antigen, such as a B7-H3 antigen or an EpCAM antigen. The compositions and methods of this disclosure are useful in treating various diseases or conditions, such as cancer, and, in some embodiments, can advantageously improve specific expression of a ROR1 binding protein to target diseased cells. |