| abstract |
The purpose of the present invention is to provide a novel T-type calcium channel blocker. A compound represented by general formula (I), a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof or a solvate of the same is used as a T-type calcium channel blocker. (In the formula: A represents optionally substituted phenyl, a 4-6 membered heteroaryl ring consisting of, as ring-constituting atoms, 1-3 heteroatoms, said heteroatoms being the same or different and selected from an oxygen atom, a sulfur atom and a nitrogen atom, and carbon atom(s), or a hetero fused ring consisting of the heteroaryl ring and a benzene ring or a 6-membered heteroaryl ring consisting of 1-2 nitrogen atoms and carbon atoms (wherein the heteroaryl ring and the hetero fused ring are optionally substituted) and is bonded to the nitrogen atom of the adjacent cyclic amine through a carbon atom constituting the ring; B represents optionally substituted phenyl, a 5- or 6-membered heteroaryl ring consisting of, as ring-constituting atoms, 1-3 heteroatoms, said heteroatoms being the same or different and selected from an oxygen atom, a sulfur atom and a nitrogen atom, and carbon atoms, or a hetero fused ring consisting of the heteroaryl ring and a benzene ring or a 6-membered heteroaryl ring consisting of 1-2 nitrogen atoms and carbon atoms (wherein the heteroaryl ring and the hetero fused ring are optionally substituted) and is bonded to the adjacent cyclopropyl ring through a carbon atom constituting the ring; R1 and R2 may be either the same or different and represent a hydrogen atom, a halogen atom, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; n and m may be either the same or different and represent 0 or 1; and p represents 1 or 2.) |