http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020016903-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbf084d77f90d7b1599746a987a45349 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 |
| filingDate | 2019-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0316bbb195311e31dcf4e73bfa885f17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b8c3b82eeb843ce08e3aae58b17741b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6375d567cdc797776fe650aca9968d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a159af7d76dc3ef08eb3c6bcf0647f92 |
| publicationDate | 2020-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020016903-A1 |
| titleOfInvention | An improved and commercially viable process for preparation of pyrrole derivatives with improved impurity profile & minimisation of unit operations. |
| abstract | The present invention relates to improved process for the preparation of a pyrrole derivative as a racemic mixture, an enantiomer, a diastereoisomer, a mixture thereof, a tautomer thereof or a pharmaceutically acceptable salt and hydrates thereof and also intermediates involved therein. Particularly invention is directed to improved processes for the preparation of pyrrole derivatives such as (4R,cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluorophenyl)-5-(1-methyl-ethyl)-pyrrole-1-yl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester of formula IV followed by its conversion into [R-(R*, R*]-2-(4-fluorophenyl)- β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1- heptanoic acid particularly calcium salt and its hydrate represented by Formulae I/IA respectively wherein formation of the impurities is either eliminated or minimized in the corresponding intermediaries. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113373187-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114195670-A |
| priorityDate | 2018-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 340.