| abstract |
Provided are a polyethylene glycol-b-polytyrosine-lipoic acid copolymer, polypeptide micelle, method for preparation thereof, and application thereof. First, a PEG-PTyr-LA polypeptide copolymer is prepared by means of NCA ring-opening polymerization and an esterification reaction; the method is simple and controllable, and the prepared polymer has good biocompatibility and biodegradability. Then, the polymer is self-assembled to obtain a micelle having a small particle size, good stability, reduction responsiveness, and a high drug loading amount. The micelle drug can circulate in vivo for a long time, and penetrates tumor tissues better, greatly improving the enrichment of the drug at the tumor and thus also better inhibiting the growth of an MDA-MB-231 breast cancer transplantation tumor. |