| abstract |
The present invention relates to: an oncolytic adenovirus capable of co-expressing interleukin-12 and a c-met-inhibiting oligonucleotide; and an anti-tumor immune-boosting composition and an anti-cancer composition which comprise same. In the present invention, an adenovirus system having simultaneous effects of IL-12 expression and c-met inhibition during cancer gene treatment has been identified for the first time, and an adenovirus system of the present invention simultaneously expresses interleukin-12 and inhibits c-met so as to restore immune functions in a tumor environment, thereby enhancing anti-cancer effects such as the inhibition of tumor recurrence and tumor growth and inhibiting tumor metastasis, and thus the present invention can be effectively used in the treatment of cancer. |