http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020009320-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_050fc7b82c5d17d9aeb63a7cdcc546b3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-603 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-148 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0654 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 |
| filingDate | 2019-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81f703e9dcadddc44684b51ccd5483cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c350c687c585fff66ffefd4b496f13d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d35f33067b7d46404af272f802688e0 |
| publicationDate | 2020-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2020009320-A1 |
| titleOfInvention | Composition comprising oct4 for inducing direct transdifferentiation into bone-related cell |
| abstract | The present invention provides: a method for direct transdifferentiation of somatic cells into bone-related cells, the method comprising a step of treating the somatic cells with at least one OCT4 (OCTamer-binding transcription factor 4) expression promoting factor of OCT4 protein or a fusion thereof, a nucleic acid molecule coding for the protein, and a vector carrying the nucleic acid molecule, and a musculoskeletal growth factor; the bone-related cells obtained thereby; a cell therapy product using same; a therapeutic material screening method using same; and a diagnostic composition using same. The present invention also provides: a composition comprising at least one OCT4 expression promoting factor of OCT4 protein or a fusion thereof, a nucleic acid molecule coding for the protein, and a vector carrying the nucleic acid molecule as an effective ingredient for preventing or treating a bone-related disease; and a preventive or therapeutic method using same. Furthermore, the present invention provides a cell-penetrating carrier-fused OCT4 protein fusion or a cell-penetrating carrier-fused OCT4 protein fusion having a bone tissue-specific carrier conjugated thereto. |
| priorityDate | 2018-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 255.