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publicationDate 2020-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020008442-A3
titleOfInvention Biopharmaceutical agents for use in reducing lipid content in cells
abstract This disclosure relates to a biopharmaceutical agent including a 37 kDa/67 kDa laminin receptor precursor/ high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use treatment and/or prevention of atherosclerosis and/or obesity and/or insulin resistance and/or diabetes. The biopharmaceutical agent may be encapsulated by functionalized or non-functionalized nanoparticles, and further may be formulated to include a carrier to provide a pharmaceutical composition for parental or non-parental administration. In use, the biopharmaceutical agent reduces lipid content in target cells. The disclosure also relates to a method of decreasing lipid concentration in a target cell of a human or animal subject.
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