| abstract |
An in vitro method of determining the in vivo immunostimulating effect resulting from pharmacological inhibition of Vps34 by a Vps34 inhibitor is disclosed, comprising: in vitro analysing a test sample originating from a source to determine a level of at least one biomarker, wherein the at least one biomarker is selected from the group consisting of CCL2, CCL3, CCL4, CCL5, CXCL9, CXCL10, CXCL11 and IFNγ, and preferably selected from CCL5 and CXCL10, wherein an elevated level of said at least one biomarker in said test sample, relative to a reference level, indicates immunostimulation in said source. |