| abstract |
Disclosed is a method for synthesizing 2,4,6-trifluorobenzylamine, belonging to the technical field of chemical synthesis, and comprising the following steps: (1) reacting pentachlorobenzonitrile as a raw material in 2,4,6-trifluoro-3,5-dichlorobenzonitrile as a solvent with a fluorinating agent for a fluorination reaction to obtain 2,4,6-trifluoro-3,5-dichlorobenzonitrile; (2) subjecting the 2,4,6-trifluoro-3,5-dichlorobenzonitrile obtained in step (1) to reduction by hydrogenation with hydrogen in the presence of an organic carboxylic acid and using palladium charcoal as a catalyst, so as to obtain 2,4,6-trifluoro-3,5-dichlorobenzylamine; and (3) subjecting the 2,4,6-trifluoro-3,5-dichlorobenzylamine obtained in step (2) to reduction by hydrogenation with hydrogen in a solvent under the action of the catalyst, so as to obtain 2,4,6-trifluorobenzylamine. The synthesis method has advantages such as a low raw material cost, a short reaction procedure, a high reaction yield, a good product purity, simple operation, and is suitable for application in industrial production. |