| abstract |
A humanized anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, or a binding fragment thereof, wherein the antibody or the binding fragment includes a heavy-chain variable domain that comprises framework region sequences derived from a human immunoglobulin and the following complementarity determining region (CDR) sequences: HCDRI (SEQ ID NO: 3), HCDR2 (SEQ ID NO: 4), HCDR3 (SEQ ID NO: 5), and a light-chain variable domain that includes framework region sequences from a human immunoglobulin and the following CDR sequences: LCDR1 (SEQ ID NO: 6), LCDR2 (SEQ ID NO: 7), and LCDR3 (SEQ ID NO: 8). |