| abstract |
A biologically active complex having anti-tumour activity, consisting of a peptide of at least amino acids, comprising an alpha-helical structure; and oleic acid or an oleate salt, in a ratio of at least 3 oleic acid or oleate salt molecules per peptide molecule, wherein, when present in the complex, the peptide has an increased conformational fluidity of three dimensional structure as compared to the peptide alone as indicated by an increased peak width on at least some 1H NMR peaks of the complex as compared to the corresponding width of the peaks of a 1H NMR of the peptide alone;provided the peptide is other than alpha-lactalbumin, SAR 1, HOPS/CORVET, SEA (Sehl-associated), Snf7 domain subunits, SEQ ID NO: 10-16, or fragments thereof having 20 or more amino acids. The complexes are biologically active and may be useful in the treatment of cancer. |