| abstract |
The present disclosure provides compounds that modulate protein function of 1 L-1β, IL-2, IL-6, TNF-α, CK1α, GSPT1, aiolos, ikaros or helios, to restore protein homeostasis, and 1 cell-cell adhesion. The disclosure provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators are provided. Uses of compounds for treatment or amelioration of diseases, disorders, or conditions associated with a protein, are also provided. |