| abstract |
A patterned flow cell includes a substrate (100, 200) having a patterned array of metal oxide nano-patches (104, 202). Each of the metal oxide nano-patches (104, 202) has an organophosphate coating layer (106, 206) to increase the ability of the metal oxide (104, 204) to bind with DNA, proteins, or polynucleotides. A silane coating layer (108, 208) is deposited in the interstitial spaces on the substrate (100, 200) between the metal oxide nano-patches (104, 202) to prevent the binding of polynucleotides, DNA, or proteins in the interstitial spaces. |