| abstract |
The present invention addresses the problem of providing: a novel kinase inhibitor and others; and a therapeutic agent for a disease, a drug discovery screening method and others, each utilizing the inhibitor and others. A compound represented by formula (I) or a salt thereof can inhibit multiple kinases including LATS (particularly LATS2) that is a major kinase involved in the Hippo signal transduction pathway, and can treat a disease or a damaged tissue both associated with cell proliferation failure. Accordingly, the present invention is useful in the field of study on cell functions, diseases and the like in which the Hippo signal transduction pathway is involved. The present invention is also useful in the medical field for treating the diseases and the like. {In the formula, each symbol is as defined in the description.} |