http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019231361-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f95a353deac58e3bc3c9f0949eb5912d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate | 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b27727f370fb19002cc24192034f6f19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_259ca6e81d966355bc045548466bfe86 |
| publicationDate | 2019-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019231361-A1 |
| titleOfInvention | Dna aptamers which interact with prothrombin |
| abstract | The invention relates to the field of nanobiotechnology and molecular medicine, and concerns DNA aptamers to thrombin exosite I that actively interact with prothrombin; these compounds can be used to create medicinal preparations that halt intravascular clot formation. The proposed aptamers bind with and inhibit not only thrombin but also its precursor, prothrombin, which is continually present in the bloodstream, and thereby exerts an inhibitory effect at the earlier stages of the circulatory system. The claimed DNA aptamers form complexes with both thrombin and prothrombin with high specificity. They can be used to create medicinal preparations that halt intravascular clot formation, which is fraught with serious consequences: stroke, heart attack, and others. The advantages of DNA aptamers include the creation of an antidote, i.e. a molecule that will break up the aptamer-protein complex. In addition, DNA aptamers do not cause allergic reactions in the body. |
| priorityDate | 2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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