| abstract |
The present invention relates to a microneedle sheet comprising a substrate sheet and a plurality of microneedles on the substrate sheet, wherein the microneedle has a height of from 50 to 1000 microns, preferably from 100 to 300 microns, and more preferably from 150 to 250 microns, the microneedle comprises at least one water-soluble or water-dispersible polymer, and the microneedle comprises at least one C-glycoside. It is possible by the present invention to effectively deliver C-glycoside such as C-xyloside to below the stratum comeum of the skin, i.e., the epidermis and/or dermis of the skin, preferably the dermo-epidermal junction of the skin. |