| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c496ef2d3e3300de56f92d1342f4f4e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00 |
| filingDate |
2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9e562ad2c9cfd29f790c072eff7b626
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8306a45a1fbd98eefb16b056eedb7597
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_275ca442c3b60745229f4775db5a8228
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bac52f640b23facf18df94a711faff74 |
| publicationDate |
2019-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019229764-A1 |
| titleOfInvention |
Process for production of recombinant tnk-tpa by packed-bed perfusion system |
| abstract |
The present invention pertains to an economic packed-bed perfusion system for the production of pharmaceutical grade of recombinant TNK-tPA. The present invention involves a cell culture process utilizing CHO cells more specifically in a micro/macro carriers based packed-bed perfusion system. The process of the present invention results in optimum cell growth and maintenance, and minimal build-up of toxic by-products such as lactate and ammonia. The system of the present invention discloses optimized process parameters to enable a resultant TNK-tPA with high yield and pharmaceutical grade purity. The process of the present invention is industrially applicable and possesses economy of scale. |
| priorityDate |
2018-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |