http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019229489-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03c4720e107878f494e6eb5a8e8500ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37b36726b8c2d3a2fe627ab8caf1e052 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 |
| filingDate | 2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b6b14737177377b411dcf911957fa93 |
| publicationDate | 2019-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019229489-A1 |
| titleOfInvention | Use of mir-146a-5p and mir-186 as biomarkers of osteoarthritis |
| abstract | Osteoarthritis (OA) is the most frequent chronic musculoskeletal disease affecting approximately 40% of adults aged 70 years and over. The inventors investigated the associations of prevalent and incident knee osteoarthritis (OA) with the expression levels of serum miRs in subjects with and without OA. By real-time PCR, they analyzed the expression levels of 19 miRs at baseline selecting 43 women with prevalent OA (Kellgren Lawrence score of 2/3), 23 women with incident OA over a 4 years follow-up and 67 healthy subjects without prevalent or incident OA matched for age and body mass index. miR-146a-5p was significantly increased in the group of prevalent OA compared with controls (RQ: relative quantification; median [Interquartile range]: 1.12 [0.73; 1.46] vs 0.85 [0.62; 1.03], p=0.015). The likelihood of prevalent OA was significantly increased (odds-ratio [95% confidence interval (CI)]: 1.83 [1.21-2.77], p=0.004) for each quartile increase in serum miR-146a-5p. There was a significant association between baseline miR-186 levels and the risk of incident OA (Q4 vs Q1-3; odds- ratio [95% CI]: 6.13 [1.14-32.9], p=0.034). In conclusion the inventors showed for the first time that miR-146a-5p and miR-186 are significantly associated with prevalent and incident OA respectively. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111621562-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111621562-A |
| priorityDate | 2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 270.