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filingDate 2019-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2019224163-A1
titleOfInvention Endogenous labelling of extracellular vesicles
abstract Use of a fluorophore to endogenously label extracellular vesicles, such as exosomes and microvesicles. Endogenous labelling (route A) is different from exogenous labelling (route B) since the extracellular vesicles are labelled when they are secreted from a cell. The labelling can take place in vitro. For example, a process for labelling extracellular vesicles comprises incubating cells in a culture medium in the presence of a fluorophore whereby the fluorophore is taken up by the cells. Then the extracellular vesicles are secreted from the cells together with the fluorophore to yield fluorophore labelled extracellular vesicle, which are isolated.
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