http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019219831-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6c945f182833bcc8718c1244788bc30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73e1811d43cc130de2daafc08fecf8eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f5aef6c426a07b053aa061f946ce4f68 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbfa1e47db419b8905dda38bb8320bbd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f7e4cb2947746342c957a219a39f3e8 |
| publicationDate | 2019-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019219831-A1 |
| titleOfInvention | Blood biomarkers of stroke |
| abstract | Stroke is a devastating disorder that significantly contributes to death, disability and health care costs. The current challenge is to prevent late cell death, with concomitant therapy to widen the therapeutic window. A potential diagnostic method for stroke is the use of RNA in the blood as a biomarker, which is an emerging field in medicine. Here the inventors explore the expression of genes after the onset of cerebral ischemia in the brain and blood. The study of macaque microarray expression data from brain and blood revealed that ischemic and nonischaemic samples can be distinguished based on their expression profiles, and the majority of highly differentially expressed genes are up- regulated in the ischemic scenario 6 hours after ischemia. A comparison of differentially expressed genes in the brain and the blood revealed a significant overlap of gene expression patterns. The data showed that there is a common signature between the ischemic brain and the blood and support the development of blood transcriptomics as a tool for biopsy transcriptome expression profiling to characterize patients with ischemic stroke to develop a companion biomarker for the assessment of neuroprotection drugs in patients. |
| priorityDate | 2018-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 525.