| abstract |
The present invention relates to a combination of microbes, cell culture systems and microfluidic fluidic systems for use in providing a human Intestine On-Chip with optimal intestinal motility. More specifically, in some embodiments, a microfluidic chip containing intestinal epithelial cells co-cuitured with intestinal endothelial cells in the presence of bacteria, such as probiotic bacteria, may find use in providing an Intestine- On-Chip for testing intestinal motility function. In some embodiments, an Intestine On- Chip may be used for identifying (testing) therapeutic compounds continuing probiotic microbes or compounds for inducing intestinal motility' for use in treating gastrointestinal disorders or diseases related to intestinal function. |