| abstract |
Disclosed herein include systems, methods, compositions, and kits for sample analysis, in particular single cell analysis. Nucleic acid fragments comprising a capture sequence (or a complement thereof) can be generated from double-stranded genomic deoxyribonucleic acid (gDNA), e.g. using a transposome, barcoded to generate single-stranded DNA (ssDNA) fragments with a cell label / identifier, and sequenced. Information relating to the gDNA (e.g., genome, chromatin accessibility, methylome) can be determined based on the sequences of the ssDNA fragments in the sequencing data obtained. |