| abstract |
One embodiment of the present invention provides a nucleic acid molecule which induces an immune response to a Zika virus infection and in which some or all of the nucleic acids constituting (i) a gene encoding a signal peptide located upstream of a gene encoding a pre-membrane (prM) protein; (ii) a gene encoding a pre-membrane (prM) and a transmembrane protein thereof; and (iii) a gene encoding an envelope (E) and a transmembrane protein thereof, of a Zika virus, are substituted, deleted, or inserted, wherein the genes (i), (ii), and (iii) of the Zika virus are inserted instead of genes of a 17D vaccine of yellow fever virus in the loci of (i) a gene encoding a signal peptide located upstream of a gene encoding a pre-membrane (prM) protein; (ii) a gene encoding a pre-membrane (prM) and a transmembrane protein thereof; and (iii) a gene encoding an envelope (E) and a transmembrane protein thereof. |