| abstract |
Provided is a substance capable of effectively inhibiting cancer metastasis or a medicinal composition effectively acting on an inflammatory disease. The medicinal composition, which comprises an antibody having an antigen binding activity to a S100A8/A9 heterodimer or an antibody fragment thereof as an active ingredient, blocks interaction between S100A8/A9 and receptors thereof and thus strongly inhibits cancer metastasis both in vitro and in vivo or ameliorates inflammation. Namely, the anti-S100A8/A9 antibody or an antibody fragment thereof has an effect of blocking the interaction between S100A8/A9 and the receptors thereof and thus can strongly inhibit cancer metastasis or ameliorate inflammation. |