| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5bf183028b18c7ce5d967a20b53e8ea |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate |
2019-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6977e746c464f0c57bd0c9cddda5c348
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b52e8d6badfd34656c18f3f3e11cf62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d00d4af8fabdd185d63373556300359
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b31823aa5674cbcc04129d0036af2b55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bf003bd7e76b22799535023ce996016 |
| publicationDate |
2019-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019207427-A2 |
| titleOfInvention |
Thioether cyclic peptide amylin receptor modulators |
| abstract |
The present invention relates to amylinomimetic peptide analogues and derivatives thereof in which the N-terminus of each peptide is covalently linked to an internal amino acid side chain thiol functionality by way of a non-peptidyl cyclization bridging element. The thioether-cyclized amylinomimetic analogues and derivatives thereof may comprise one or more alterations including substitutions, insertions, deletions and modifications and may optionally comprise a serum albumin binding element, such as an alkyl chain of at least 14 carbon atoms optionally bearing an additional pendant carboxylate moiety, or a half-life extending biologic moiety, such as HSA, a non-targeting mAb or Fc. Moreover, the invention relates to compositions thereof and methods of treatment of conditions responsive to amylin receptor modulation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11744873-B2 |
| priorityDate |
2018-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |