| abstract |
The present invention provides a compound as represented by formula (1), or a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorph, an isotopic label, an isomer, or a prodrug thereof. The present invention also provides a pharmaceutical composition comprising same, and the use of the compound and the pharmaceutical composition in preparation of drugs for treating tyrosine kinase-mediated diseases. The compound and the pharmaceutical composition comprising same provided by the present invention have significant tyrosine kinase inhibitory activity, can overcome tumor drug resistance and break through blood-brain barrier, also have excellent pharmacokinetic properties and excellent oral bioavailability, and can be administered in a small dosage, thereby reducing treatment costs of and possible side effects to a patient. Thus, the application potential is very great. |