| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d735fdce340cadbfe77bb774d40ea09 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c4c0cc89be77e9182b65d6a703f6a22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d32da6720e33b45df838f51150755bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a4bc3276a93f2d8e7926ff5d23778ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_873ff485d50a1f48390c71d8c208b4da
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4329323fcb71b245af0d4e4eb8576851 |
| publicationDate |
2019-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019204989-A1 |
| titleOfInvention |
Cd4-positive cell-specific dna aptamer and chimera thereof |
| abstract |
Provided are a CD4-positive cell-specific DNA aptamer and a chimera thereof. A CD4-positive cell-specific DNA aptamer is constructed by combining nucleic acid aptamer technology with RNAi technology which have a cell targeting function, and an anti-cancer siRNA is selectively introduced into CD4-positive tumor-associated macrophages. The function of delivering anti-cancer siRNA and the anti-tumor effect of the CD4-positive cell-specific DNA aptamer acting as a vector guide tool is detected in tumor-associated macrophages and breast cancer cell culture systems in vitro. A novel gene anti-cancer drug based on targeted RNAi is provided, and a new idea for the development of the targeted introduction of RNAi into a target cell is simultaneously provided. |
| priorityDate |
2018-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |