| abstract |
Microneedle and microneedle devices including implantable silk-based tips for sustained dermal delivery of a vaccine, kits, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for controlled- or sustained- administration of a vaccine (e.g., an influenza vaccine) to provide improved immunogenicity and/or broad- spectrum immunity to a subject are also described. |