http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019191232-A3

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filingDate 2019-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2019191232-A3
titleOfInvention Nucleic acid molecules for pseudouridylation
abstract The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.
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