| abstract |
Provided is a biologically relevant substance to which is bonded a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation in cells. A biologically relevant substance to which is bonded a degradable polyethylene glycol derivative that is represented by formula (A). (In the formula, m is 1–7, n1 and n2 are each independently 45–682, p is 1–4, R is a C1–4 alkyl group, Z is a 2–8-residue oligopeptide that comprises neutral amino acids other than cysteine, Q is a residue of a compound that has 2–5 active hydrogens, D is the biologically relevant substance, L1, L2, L3, L4, and L5 are each independently a single bond or a bivalent space, and y is 1–40.) |