| abstract |
The present invention relates to a composition and a method of use thereof, such as for treating reactive gliosis in a subject. The method includes administering to the subject a pharmaceutical composition comprising a polynucleotide encoding an antisense sequence complementary to the inhibitor kappa B kinase-β (IKKB) gene or a transcript thereof, wherein the polynucleotide is transcribed, in an activated microglia cell and not in a resting microglia cell. |