| abstract |
The present invention relates to a sustained release formulation of bethanechol and a process for preparing the same. More specifically, the present invention relates to a sustained release formulation of bethanechol for once-a-day oral administration comprising (i) a matrix preparation formed from granules comprising bethanechol or a pharmaceutically acceptable salt thereof as an active ingredient, and a mixture of a swellable polymer and a water-insoluble polymer; and (ii) a coating layer comprising a mixture of an insoluble polymer and a hydrophilic polymer, coating the matrix preparation; and a process for preparing said formulation. The sustained release formulation for once-a-day oral administration according to the present invention can form a hydrogel while using a minimum amount of polymer, is thereby capable of continuously releasing bethanechol in a controlled manner for 24 hours, and has a suitable size for taking, which can improve the convenience of administration. |