http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019180664-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7c3d76288892ddbddca3e1fe2313ec5c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 |
| filingDate | 2019-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_915477a66cd8df0e7be1d34e6ee5a35f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84b8cb43dbd5ecae6111bdcac96787d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb6c12f5a6045aaef0e34bcf3b18d960 |
| publicationDate | 2019-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019180664-A1 |
| titleOfInvention | Method for preventing or modulating fibrosis and fibrotic response associated with the integrated stress response |
| abstract | What is described is a method of preventing, ameliorating and/or treating fibrosis or fibrotic response associated with the integrated stress response (ISR) involving the eukaryotic Initiation Factor 2 (eIF2), phosphorylated eukaryotic initiation factor 2α (p-eIF2α) and PKR-like endoplasmic reticulum kinase (PERK) pathway arising from various cellular stresses, such as oxidative stress, hypoxia and ER stress, chronic or prolonged bio-mechanical stress and others. In one embodiment, it provides a method which prevents or alleviates aberrant cell differentiation caused by the activation of the integrated stress response and thereby prevents, treats or alleviates fibrosis or fibrotic response resulting therefrom. In another embodiment, it provides a method of using a p-eIF2α-modulator or a phosphorylated eukaryotic initiation factor 2βmodulator (p-eIF2β-modulator) for the prevention, amelioration and/or treatment of fibrosis or fibrotic response described herein. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114672547-A |
| priorityDate | 2018-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 674.