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filingDate 2019-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2019177151-A1
titleOfInvention Genetically modified cell and producing method therefor
abstract Provided is a production of a cell expressing a variant chimeric antigen receptor (CAR) having excellent target cytotoxicity. Provided is a genetically modified cell into which a polynucleotide is introduced, the polynucleotide encoding a chimeric antigen receptor (CAR) protein having: a target binding domain which specifically binds to a human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor; a transmembrane domain; and an intracellular signaling domain, wherein the target binding domain is a variant in which a glutamic acid of the 21 st in the amino acid sequence represented by SEQ ID NO: 1 is substituted with another amino acid.
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