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filingDate 2019-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9559f7cb2e11258b018de6ee2cf60096
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publicationDate 2019-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2019175449-A1
titleOfInvention Magnetic nanoparticles for use in assisted reproduction
abstract The present invention relates to a method of preparing magnetic oocytes and/or embryos by means of nanoparticles for assisted reproduction techniques and for use in assisted reproduction techniques of non-human oocytes and/or embryos prepared with said method. Said method comprises: a step in which magnetic nanoparticles are conjugated with oviduct recombinant protein, OVGP1r; a step in which the attachment of the nanoparticle/ OVGPlr conjugate to the pellucid zone (ZP) of oocytes/embryos after their common incubation is verified; and a step in which the number of oocytes/embryos having nanoparticles attached to them distributed around the ZP without being absorbed by endocytosis is verified; and the amount of magnetic nanoparticles attached to the ZP of oocytes/embryos is assessed to ascertain whether it is sufficient for them to be attracted by a magnetic field.
priorityDate 2018-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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