| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_376909b3a516106111a9a857c89aa8d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae0795bfe2e63764a9196746cb24d1c3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3683
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B33Y70-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B33Y80-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B33Y80-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B33Y70-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-26 |
| filingDate |
2019-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d56bc7645cf86ff392692e2ffb9f5630
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0de14f9072b1145f8ec0be075384e9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a42321763e11f67ccfbcc4a05a50dd5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5de8d068b9de7859eb7a5aed5ed4fa86 |
| publicationDate |
2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019173637-A1 |
| titleOfInvention |
Nanocellulose-containing bioinks for 3d bioprinting, methods of making and using the same, and 3d biostructures obtained therefrom |
| abstract |
Some variations of the invention provide a bioink composition for 3D bioprinting, comprising: nanocellulose in the form of nanocellulose crystals, nanocellulose fibrils, or preferably a combination thereof; alginate that is ionically crosslinkable in the presence of an ionic crosslinking agent; and water. The nanocellulose-alginate bioinks have favorable rheological, swelling, and biocompatibility properties for extrusion-based bioprinting. It is experimentally demonstrated that nanocellulose-alginate bioinks with human nasoseptal chondrocytes enable cartilage bioprinting at high resolution. The disclosed nanocellulose has been proven to be compatible with cell survival and proliferation; to possess nanoscale and microscale architectures mimicking the native extracellular environment, encouraging differentiation and tissue formation; and to have ideal rheological properties to allow extrusion 3D bioprinting. Bioink with a unique blend of crystal and fibril nanocellulose produces a very stable construct volume in culture. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021041962-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-3111904-A1 |
| priorityDate |
2018-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |