| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f2869eb6583013e2043de9b486836de |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2015-859
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-43534
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0318
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0393
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2015-8536 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0336
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5085 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
| filingDate |
2019-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fce83fa597b98fcc2764237289be738
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29187ab1510767c8b3d969906bf941f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ddddb6f1a961d434aa1f81794d76515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_642fe578232d78c9a4fb9b71afcadf7c |
| publicationDate |
2019-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019165128-A1 |
| titleOfInvention |
Transgenic animal phenotyping platform and uses thereof |
| abstract |
The present disclosure provides transgenic nematode systems for assessing function of heterologous genes, their variants and drug discovery. The transgenic nematodes contain a heterologous gene that is inserted via homologous recombination at the native locus replacing and removing the nematode ortholog, wherein expression of the heterologous gene rescues function of the removed nematode ortholog and a transgenic control animal is provided. The heterologous gene may be further modified to provide a variant, such as a human clinical variant, whereby a transgenic test animal is provided. Those transgenic test animals are used in methods to assess function of the heterologous variant and drug screens to find therapeutic candidates reversing deviant activity back to wildtype. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113528584-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021127651-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11477967-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022268739-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021076790-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113528584-B |
| priorityDate |
2018-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |