| abstract |
Provided in the present invention are a substituted nicotinamide compound and a composition comprising same and the use thereof. The substituted nicotinamide compound is a compound as shown in formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate or solvate, crystal form, stereoisomer or isotopic variant thereof. The compound of the present invention can inhibit the tyrosine kinase activity of Abelson protein (ABL1), Abelson-related protein (ABL2) and related chimeric proteins, particularly Bcr-Abl1, and has better pharmacokinetic properties. |