| abstract |
Provided are a substituted diaminopyrimidine compound as represented by formula (I), or a pharmaceutically acceptable salt, crystal form, prodrug, metabolite, hydrate, solvate, stereoisomer or isotopic derivative thereof, and a pharmaceutical composition and use thereof. The compound can be used to treat ALK-mediated related diseases such as non-small cell lung cancer, breast cancer, neural tumors, esophagus cancer, soft tissue cancer, lymphoma and leukemia. |