http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019153324-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9de52bba13e16028dffa8775e3f3f28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-69 |
| filingDate | 2018-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fecf92d8c09dd7d1b22e53df86f8612 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e712c16ff07090ed5f481bf7e138c9ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc31c5bcdedba4de534019552ab2bbc0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6e12737c0ec2a22dff125313dec379d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_714e571d794171eb088bf038e40bcb3d |
| publicationDate | 2019-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2019153324-A1 |
| titleOfInvention | Derivatives of 7-fatty acid substituted benzoxaborole and their preparation and use |
| abstract | The present disclosure relates to derivatives of 7-fatty acid substituted benzoxaborole and their preparation and use. The structural general formula of the derivatives is (I). The derivatives are used for the preparation of a medicament for the prevention and treatment of tumors. Compared with the prior art, the present derivatives inhibit the proliferation of tumor cells at the nanomolar level, and have relatively low toxicity to normal human cell lines, the compounds have obvious inhibition to proliferation of tumor cells in a tumor-bearing nude mouse model, and therefore can prevent and treat tumors, especially tumor cell lines such as ovarian cancer SKOV3, breast cancer MDA-MB231, and colon cancer HCT116, but are not limited to the aforesaid tumor cell lines; the normal human cell lines include but are not limited to MCF-10A and WI-38 and others normal cell lines. |
| priorityDate | 2018-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 111.