| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_777683f026610892af9548900641b318 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8258
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2887
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2018-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_574869bc865099813549e5559486dfd8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1497f9b60e03df6fe61825cc2080c7ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f055668af6fdd499f7a3d3c118a3772d |
| publicationDate |
2019-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019148938-A1 |
| titleOfInvention |
Application of plant as host in expression of rituximab |
| abstract |
An application of a plant as a host in the expression of rituximab, a plant, such as lettuce, is used as an expression platform for recombinant protein production, and an Agrobacterium-mediated vacuum infiltration method is used to express a rituximab monoclonal antibody. The expression system determines that a foreign plant protein can be collected after four days of Agrobacterium infection. Successful expression of recombinant rituximab is determined by using a method of sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE). Burkitt lymphoma inhibiting experiments demonstrate that rituximab produced by lettuce has the biological activity of inhibiting lymphoma cells. |
| priorityDate |
2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |